近年来，深度学习（DL）方法的流行程度急剧增加，并且在生物医学科学中的监督学习问题中的应用显着增长。但是，现代生物医学数据集中缺失数据的较高流行率和复杂性对DL方法提出了重大挑战。在这里，我们在深入学习的广义线性模型的背景下，对缺失数据进行了正式处理，这是一种监督的DL架构，用于回归和分类问题。我们提出了一种新的体系结构，即\ textit {dlglm}，这是第一个能够在训练时在输入功能和响应中灵活地说明忽略和不可忽视的缺失模式之一。我们通过统计模拟证明，我们的方法在没有随机（MNAR）缺失的情况下胜过现有的监督学习任务方法。我们从UCI机器学习存储库中对银行营销数据集进行了案例研究，在该数据集中我们预测客户是否基于电话调查数据订阅了产品。

近年来，深度学习（DL）方法的流行程度大大增加。尽管在图像数据的分类和操纵中证明了其最初的成功，但DL方法应用于生物医学科学中的问题的应用已显着增长。但是，生物医学数据集中缺失数据的较高流行率和复杂性对DL方法提出了重大挑战。在这里，我们在变化自动编码器（VAE）的背景下提供了对缺失数据的正式处理，这是一种普遍用于缩小尺寸，插补和学习复杂数据的潜在表示的流行无监督的DL体系结构。我们提出了一种新的VAE架构Nimiwae，这是第一个在训练时在输入功能中灵活解释可忽视和不可忽视的缺失模式之一。训练后，可以从缺失数据的后验分布中得出样本，可用于多个插补，从而促进高维不完整数据集的下游分析。我们通过统计模拟证明，我们的方法优于无监督的学习任务和插定精度的现有方法。我们以与12,000名ICU患者有关的EHR数据集的案例研究结束，该数据集具有大量诊断测量和临床结果，其中仅观察到许多特征。

A comprehensive pharmaceutical recommendation system was designed based on the patients and drugs features extracted from Drugs.com and Druglib.com. First, data from these databases were combined, and a dataset of patients and drug information was built. Secondly, the patients and drugs were clustered, and then the recommendation was performed using different ratings provided by patients, and importantly by the knowledge obtained from patients and drug specifications, and considering drug interactions. To the best of our knowledge, we are the first group to consider patients conditions and history in the proposed approach for selecting a specific medicine appropriate for that particular user. Our approach applies artificial intelligence (AI) models for the implementation. Sentiment analysis using natural language processing approaches is employed in pre-processing along with neural network-based methods and recommender system algorithms for modeling the system. In our work, patients conditions and drugs features are used for making two models based on matrix factorization. Then we used drug interaction to filter drugs with severe or mild interactions with other drugs. We developed a deep learning model for recommending drugs by using data from 2304 patients as a training set, and then we used data from 660 patients as our validation set. After that, we used knowledge from critical information about drugs and combined the outcome of the model into a knowledge-based system with the rules obtained from constraints on taking medicine.

Text-to-text generation models have increasingly become the go-to solution for a wide variety of sequence labeling tasks (e.g., entity extraction and dialog slot filling). While most research has focused on the labeling accuracy, a key aspect -- of vital practical importance -- has slipped through the cracks: understanding model confidence. More specifically, we lack a principled understanding of how to reliably gauge the confidence of a model in its predictions for each labeled span. This paper aims to provide some empirical insights on estimating model confidence for generative sequence labeling. Most notably, we find that simply using the decoder's output probabilities is not the best in realizing well-calibrated confidence estimates. As verified over six public datasets of different tasks, we show that our proposed approach -- which leverages statistics from top-$k$ predictions by a beam search -- significantly reduces calibration errors of the predictions of a generative sequence labeling model.

How can we accurately identify new memory workloads while classifying known memory workloads? Verifying DRAM (Dynamic Random Access Memory) using various workloads is an important task to guarantee the quality of DRAM. A crucial component in the process is open-set recognition which aims to detect new workloads not seen in the training phase. Despite its importance, however, existing open-set recognition methods are unsatisfactory in terms of accuracy since they fail to exploit the characteristics of workload sequences. In this paper, we propose Acorn, an accurate open-set recognition method capturing the characteristics of workload sequences. Acorn extracts two types of feature vectors to capture sequential patterns and spatial locality patterns in memory access. Acorn then uses the feature vectors to accurately classify a subsequence into one of the known classes or identify it as the unknown class. Experiments show that Acorn achieves state-of-the-art accuracy, giving up to 37% points higher unknown class detection accuracy while achieving comparable known class classification accuracy than existing methods.

Knowledge Distillation (KD) is a commonly used technique for improving the generalization of compact Pre-trained Language Models (PLMs) on downstream tasks. However, such methods impose the additional burden of training a separate teacher model for every new dataset. Alternatively, one may directly work on the improvement of the optimization procedure of the compact model toward better generalization. Recent works observe that the flatness of the local minimum correlates well with better generalization. In this work, we adapt Stochastic Weight Averaging (SWA), a method encouraging convergence to a flatter minimum, to fine-tuning PLMs. We conduct extensive experiments on various NLP tasks (text classification, question answering, and generation) and different model architectures and demonstrate that our adaptation improves the generalization without extra computation cost. Moreover, we observe that this simple optimization technique is able to outperform the state-of-the-art KD methods for compact models.

Data heterogeneity across clients is a key challenge in federated learning. Prior works address this by either aligning client and server models or using control variates to correct client model drift. Although these methods achieve fast convergence in convex or simple non-convex problems, the performance in over-parameterized models such as deep neural networks is lacking. In this paper, we first revisit the widely used FedAvg algorithm in a deep neural network to understand how data heterogeneity influences the gradient updates across the neural network layers. We observe that while the feature extraction layers are learned efficiently by FedAvg, the substantial diversity of the final classification layers across clients impedes the performance. Motivated by this, we propose to correct model drift by variance reduction only on the final layers. We demonstrate that this significantly outperforms existing benchmarks at a similar or lower communication cost. We furthermore provide proof for the convergence rate of our algorithm.

Supervised machine learning-based medical image computing applications necessitate expert label curation, while unlabelled image data might be relatively abundant. Active learning methods aim to prioritise a subset of available image data for expert annotation, for label-efficient model training. We develop a controller neural network that measures priority of images in a sequence of batches, as in batch-mode active learning, for multi-class segmentation tasks. The controller is optimised by rewarding positive task-specific performance gain, within a Markov decision process (MDP) environment that also optimises the task predictor. In this work, the task predictor is a segmentation network. A meta-reinforcement learning algorithm is proposed with multiple MDPs, such that the pre-trained controller can be adapted to a new MDP that contains data from different institutes and/or requires segmentation of different organs or structures within the abdomen. We present experimental results using multiple CT datasets from more than one thousand patients, with segmentation tasks of nine different abdominal organs, to demonstrate the efficacy of the learnt prioritisation controller function and its cross-institute and cross-organ adaptability. We show that the proposed adaptable prioritisation metric yields converging segmentation accuracy for the novel class of kidney, unseen in training, using between approximately 40\% to 60\% of labels otherwise required with other heuristic or random prioritisation metrics. For clinical datasets of limited size, the proposed adaptable prioritisation offers a performance improvement of 22.6\% and 10.2\% in Dice score, for tasks of kidney and liver vessel segmentation, respectively, compared to random prioritisation and alternative active sampling strategies.

The primary obstacle to developing technologies for low-resource languages is the lack of representative, usable data. In this paper, we report the deployment of technology-driven data collection methods for creating a corpus of more than 60,000 translations from Hindi to Gondi, a low-resource vulnerable language spoken by around 2.3 million tribal people in south and central India. During this process, we help expand information access in Gondi across 2 different dimensions (a) The creation of linguistic resources that can be used by the community, such as a dictionary, children's stories, Gondi translations from multiple sources and an Interactive Voice Response (IVR) based mass awareness platform; (b) Enabling its use in the digital domain by developing a Hindi-Gondi machine translation model, which is compressed by nearly 4 times to enable it's edge deployment on low-resource edge devices and in areas of little to no internet connectivity. We also present preliminary evaluations of utilizing the developed machine translation model to provide assistance to volunteers who are involved in collecting more data for the target language. Through these interventions, we not only created a refined and evaluated corpus of 26,240 Hindi-Gondi translations that was used for building the translation model but also engaged nearly 850 community members who can help take Gondi onto the internet.

Recent work has demonstrated that natural language processing techniques can support consumer protection by automatically detecting unfair clauses in the Terms of Service (ToS) Agreement. This work demonstrates that transformer-based ToS analysis systems are vulnerable to adversarial attacks. We conduct experiments attacking an unfair-clause detector with universal adversarial triggers. Experiments show that a minor perturbation of the text can considerably reduce the detection performance. Moreover, to measure the detectability of the triggers, we conduct a detailed human evaluation study by collecting both answer accuracy and response time from the participants. The results show that the naturalness of the triggers remains key to tricking readers.